SULFAPHENAZOLE

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1.What is the SULFAPHENAZOLE ?

White to off-white powder

ChEBI: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

2.What is the CAS number for SULFAPHENAZOLE ?

The CAS number of SULFAPHENAZOLE is 526-08-9.

3.What are another words for SULFAPHENAZOLE ?

Synonyms?for?SULFAPHENAZOLE 526-08-9:Sulfanilamide,N1-(1-phenylpyrazol-5-yl)- (8CI); 1-Phenyl-5-sulfanilamidopyrazole;2-Phenyl-3-sulfanilamidopyrazole;3-(p-Aminobenzenesulfonamido)-2-phenylpyrazole;5-Sulfanilamido-1-phenylpyrazole; Depocid; Depotsulfonamide; Eftolon;Firmazolo; Inamil; Isarol; Isarol V; Merian; Microtan pirazolo;N1-(1-Phenylpyrazol-5-yl)sulfanilamide; Orisul; Orisulf; Paidazolo; Plisulfan;Raziosulfa; Sulfabid; Sulfaphenazol; Sulfaphenazole; Sulfaphenazon;Sulfaphenylpyrazole; Sulphaphenazole

4.What is SULFAPHENAZOLE (526-08-9) used for?

Sulfaphenazole is used as an inhibitor for mammalian CYP2C9, an enzyme of the cytochrome P450 family allowing for pharmacological application.Sulfaphenazole can help protect against ischemia-reperfusion, and resulting tissue damage by inhibition of CYP2C9.

InChI:InChI=1/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

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5.Buy SULFAPHENAZOLE with the best price .

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